RECURRENT PREGNANCY LOSS
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Muhamad Nofa Cholili*
Arsana Wiyasa
Miscarriage occurs when the fetus is unable to survive outside the womb and the results of conception are expelled. Although the issue of RPL is still controversial, current information about the suggested treatment offers effective treatment to improve reproductive quality and can provide appropriate therapy in a woman with RPL based on the etiology. The time restriction until the fetus is pronounced viable or capable of surviving outside the womb varies by country. According to the World Health Organization, over 21.6 million abortions occurred worldwide in 2008, with almost all of these cases occur in developing countries. The risk of miscarriage increases most significantly at the age of 35 years. Women aged 35 years have twice the risk of miscarriage compared to women aged < 35 years. Antiphospholipid syndrome is a risk factor for recurrent miscarriage, which occurs in about 15% of patients. The reason of recurrent miscarriage can be linked to both fetal and maternal factors. Diagnostic examinations are not recommended in patients with recurrent miscarriage unless certain criteria are met. However, screening can be used to identify risk factors. The management of recurrent miscarriage should be addressed toward the underlying cause with a treatable etiology or pathophysiology.
Alexander, K. D., Berger, E., Fong, W., Williams, P. K. G., Guidorzi, C., Margutti, R., Metzger, B. D., Annis, J., Blanchard, P. K., & Brout, D. (2017). The electromagnetic counterpart of the binary neutron star merger LIGO/VIRGO GW170817. VI. Radio constraints on a relativistic jet and predictions for late-time emission from the kilonova ejecta. The Astrophysical Journal Letters, 848(2), L21.
Alfansury, M., & Trisetiyono, Y. (2018). KARAKTERISTIK KEGUGURAN BERULANG DI RSUP DR. KARIADI SEMARANG. DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO), 7(4), 1661–1667.
Aruna, S. T., Balaji, N., & Rajam, K. S. (2011). Phase transformation and wear studies of plasma sprayed yttria stabilized zirconia coatings containing various mol% of yttria. Materials Characterization, 62(7), 697–705.
Baek, K.-H., Choi, B. C., Lee, J.-H., Choi, H.-K., Lee, S.-H., Kim, J.-W., Hill, J. A., Chung, H.-M., Ko, J. J., & Cha, K. Y. (2002). Comparison of gene expression at the feto–maternal interface between normal and recurrent pregnancy loss patients. Reproduction, Fertility and Development, 14(4), 235–240.
Baek, K.-H., Lee, E.-J., & Kim, Y.-S. (2007). Recurrent pregnancy loss: the key potential mechanisms. Trends in Molecular Medicine, 13(7), 310–317.
C.-S., L., W.-Z., S., W.-H., C., C.-J., L., H.-M., Y., & M.S., M. (2004). Intravenous lidocaine and ephedrine, but not propofol, suppress fentanyl-induced cough. Canadian Journal of Anesthesia.
Christiansen, O. B., Andersen, A.-M. N., Bosch, E., Daya, S., Delves, P. J., Hviid, T. V, Kutteh, W. H., Laird, S. M., Li, T.-C., & van der Ven, K. (2005). Evidence-based investigations and treatments of recurrent pregnancy loss. Fertility and Sterility, 83(4), 821–839.
El Hachem, H., Crepaux, V., May-Panloup, P., Descamps, P., Legendre, G., & Bouet, P.-E. (2017). Recurrent pregnancy loss: current perspectives. International Journal of Women’s Health, 9, 331.
Franssen, M. T. M., Musters, A. M., van der Veen, F., Repping, S., Leschot, N. J., Bossuyt, P. M. M., Goddijn, M., & Korevaar, J. C. (2011). Reproductive outcome after PGD in couples with recurrent miscarriage carrying a structural chromosome abnormality: a systematic review. Human Reproduction Update, 17(4), 467–475.
Ikuma, S., Sato, T., Sugiura-Ogasawara, M., Nagayoshi, M., Tanaka, A., & Takeda, S. (2015). Preimplantation genetic diagnosis and natural conception: a comparison of live birth rates in patients with recurrent pregnancy loss associated with translocation. PloS One, 10(6), e0129958.
Jaslow, C. R. (2014). Uterine factors. Obstetrics and Gynecology Clinics, 41(1), 57–86.
Jauniaux, E., Farquharson, R. G., Christiansen, O. B., & Exalto, N. (2006). Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage. Human Reproduction, 21(9), 2216–2222.
Khalife, D., Ghazeeri, G., & Kutteh, W. (2019). Review of current guidelines for recurrent pregnancy loss: new strategies for optimal evaluation of women who may be superfertile. Seminars in Perinatology, 43(2), 105–115.
Laird, S. M., Tuckerman, E. M., Cork, B. A., Linjawi, S., Blakemore, A. I. F., & Li, T. C. (2003). A review of immune cells and molecules in women with recurrent miscarriage. Human Reproduction Update, 9(2), 163–174.
Lieng, M., Istre, O., Sandvik, L., & Qvigstad, E. (2009). Prevalence, 1-year regression rate, and clinical significance of asymptomatic endometrial polyps: cross-sectional study. Journal of Minimally Invasive Gynecology, 16(4), 465–471.
Makris, N., Kalmantis, K., Skartados, N., Papadimitriou, A., Mantzaris, G., & Antsaklis, A. (2007). Three-dimensional hysterosonography versus hysteroscopy for the detection of intracavitary uterine abnormalities. International Journal of Gynecology & Obstetrics, 97(1), 6–9.
McQueen, D. B., Bernardi, L. A., & Stephenson, M. D. (2014). Chronic endometritis in women with recurrent early pregnancy loss and/or fetal demise. Fertility and Sterility, 101(4), 1026–1030.
Metwally, M., Raybould, G., Cheong, Y. C., & Horne, A. W. (2020). Surgical treatment of fibroids for subfertility. Cochrane Database of Systematic Reviews, 1.
Miyakis, S., Lockshin, M. D., Atsumi, T., Branch, D. W., Brey, R. L., Cervera, R., Derksen, R., De Groot, P. G., Koike, T., & Meroni, P. L. (2006). International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). Journal of Thrombosis and Haemostasis, 4(2), 295–306.
Pasquier, E., de Saint Martin, L., Bohec, C., Chauleur, C., Bretelle, F., Marhic, G., Le Gal, G., Debarge, V., Lecomte, F., & Denoual-Ziad, C. (2015). Enoxaparin for prevention of unexplained recurrent miscarriage: a multicenter randomized double-blind placebo-controlled trial. Blood, The Journal of the American Society of Hematology, 125(14), 2200–2205.
Pillarisetty, L. S., & Bragg, B. N. (2020). Late Decelerations. StatPearls [Internet].
Rai, R., & Regan, L. (2006). Recurrent miscarriage. The Lancet, 368(9535), 601–611.
Ticconi, C., Pietropolli, A., Specchia, M., Nicastri, E., Chiaramonte, C., Piccione, E., Scambia, G., & Di Simone, N. (2020). Pregnancy-Related Complications in Women with Recurrent Pregnancy Loss: A Prospective Cohort Study. Journal of Clinical Medicine, 9(9), 2833.
Toth, B., Jeschke, U., Rogenhofer, N., Scholz, C., Würfel, W., Thaler, C. J., & Makrigiannakis, A. (2010). Recurrent miscarriage: current concepts in diagnosis and treatment. Journal of Reproductive Immunology, 85(1), 25–32.
Ugwumadu, A., Manyonda, I., Reid, F., & Hay, P. (2003). Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis: a randomised controlled trial. The Lancet, 361(9362), 983–988.
Van den Berg, M M J, Vissenberg, R., & Goddijn, M. (2014). Recurrent miscarriage clinics. Obstetrics and Gynecology Clinics, 41(1), 145–155.
van den Berg, Merel M J, van Maarle, M. C., van Wely, M., & Goddijn, M. (2012). Genetics of early miscarriage. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1822(12), 1951–1959.
Wang, W.-J., Hao, C.-F., & Lin, Q.-D. (2011). Dysregulation of macrophage activation by decidual regulatory T cells in unexplained recurrent miscarriage patients. Journal of Reproductive Immunology, 92(1–2), 97–102.
Wong, L. F., Porter, T. F., & Scott, J. R. (2014). Immunotherapy for recurrent miscarriage. Cochrane Database of Systematic Reviews, 10.
