RATIONALITY OF ANTIBIOTICS USE WITH QUANTITATIVE AND QUALITATIVE METHODS AT HOSPITAL IN INDONESIA
Fadhila Diah Suminar*
Infection is one of the biggest causes of death in Indonesia which can be influenced by the appropriate use of antibiotics. Irrational use of antibiotics can cause bacteria to become resistant to antibiotics so that the effectiveness of the drug decreases or even disappears. This study aims to evaluate the use of antibiotics given to inpatients at a private hospital in Indonesia both quantitatively and qualitatively in the period July to December 2021. This study is an observational study with retrospective data collection where qualitative analysis using the Gyssens Method and quantitative analysis uses the DDD method. The results of the qualitative analysis showed that from 30 cases observed, there were 9 cases (30%) irrational prescriptions, namely 1 case in category V, 4 cases in category IVA, 2 cases in category IIIB and 2 cases in category IIA. The results of the quantitative analysis showed that the antibiotics with the highest DDD/100 patient days in the period July to December 2021 were Ceftriaxone with a successive value of 39.15; 39.81; 36.22; 55.65; 41,48 and 49, 42 while antibiotics with the lowest DDD/100 patient-days values in the period July to December obtained different results. Based on research results, there are irrational antibiotic prescriptions and Ceftriaxone became the most commonly prescribed antibiotic.
American Society of Health System Pharmacists. (2011). AHFS Drug Information.
Ardyanti, A. T. (2016). Evaluation of the Rationality of Antibiotic Use in Children with Acute Diarrhea in the Inpatient Installation of Kardinah Hospital, Tegal City Period 2016.
DiPiro, Joseph T., Schwinghammer, Terry L., Cecily V., & Barbara G. (2015). Pharmacotherapy handbook.
Gyssens, I. C. (2005). Quality Measures of Antimicrobial Drug Use (Vol. 54). Acta Clin Belgica.
Indonesian Ministry of Health. (2011). General Guidelines for the Use of Antibiotics. Indonesian Ministry of Health.
Kataria, K., Srivastava, A., & Dhar, A. (2013). Management of lactational mastitis and breast abscesses: review of current knowledge and practice. Indian Journal of Surgery, 75(6), 430–435.
Ministry of Health Regulation. (2011). Regulation of the Minister of Health of the Republic of Indonesia Number 2406/Menkes/Per/XII/2011. http://www.Binfar.Depkes.Go.Id/Dat/ Permenkes_ Antibiotics.Pdf.
NICE. (2015). Skin infections, antibacterial therapy | Treatment summary. https://bnf.nice.org.uk/treatment-summary/skin-infections-antibacterial-therapy.html
Novianae, L. (2020). Analysis of Antibiotic Use in Inpatients in the Internal Medicine and Surgery Room at RSUD dr. Doris Sylvanus Palangka Raya.
Rachmawati, S., FAZERI, R. L., & Norcahyanti, I. (2020). Gambaran penggunaan antibiotik di bangsal penyakit dalam RSUD Bangil Kabupaten Pasuruan.
Rukminingsih, F., & Apriliyani, A. (2021). Analisis Penggunaan Antibiotik pada Pasien Anak di Ruang Theresia Rumah Sakit St. Elisabeth Semarang dengan Metode Atc/ddd. Jurnal Riset Kefarmasian Indonesia, 3(1), 26–34.
Samuel, S. (2019). The Post Antibiotic Era is Here. https://www.vox.com/future-perfect/2019/11/14/20963824/drug-resistance-antibiotics-cdc-report accessed on 10/01/21
Tjay, T. H., & Rahardja, K. (2007). Obat-obat penting: khasiat, penggunaan dan efek-efek sampingnya. Elex Media Komputindo.
Wells, B. J., Mainous, A. G., & Dickerson, L. M. (2004). Antibiotics for the secondary prevention of ischemic heart disease: a meta-analysis of randomized controlled trials. Archives of Internal Medicine, 164(19), 2156–2161.
WHO. (2020). WHO operational handbook on tuberculosis. https://apps.who.int/iris/rest/bitstreams/1281012/retrieve