OVERVIEW OF PERIPHERAL NEUROPATHY IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALYSIS AT DR. MOHAMMAD HOESIN HOSPITAL PALEMBANG
Main Article Content
Neurological complications occur in almost 60% of patients with advanced CKD and affect the nervous system at all levels, both central and peripheral. Peripheral neuropathy in CKD is usually asymptomatic until renal function is below 15%, and glomerular filtration is less than 10-12 ml/min. This study seeks to identify and characterize peripheral neuropathy in patients with chronic kidney disease undergoing hemodialysis at Dr. Mohammad Hoesin Hospital Palembang. This is a descriptive cross-sectional study with the research sample comprising chronic kidney disease patients undergoing hemodialysis at Dr. Mohommad Hoesin Palembang Hospital. The distribution of research subjects based on the Neuropathy Symptom Score (NSS) revealed that 65.7% fell into the mild neuropathy category, based on an NSS of 3-4. According to the electrophysiology results, 82.9% of patients exhibited peripheral neuropathy, while 17.1% showed normal NCS results. Sensory motor neuropathy accounted for 51.4%, including 71.5% with axonal neuropathy, 11.4% with axonal-demyelinating lesions, and no demyelinating lesions. The high prevalence of peripheral neuropathy in CKD patients identified through electrophysiological examination (ENMG) emphasizes the importance of nerve conduction examination as a diagnostic tool for peripheral neuropathy in CKD patients. This can aid in determining the progression of peripheral neuropathy in CKD patients, allowing for appropriate management and prevention of disability complications to enhance the quality of life for these individuals.
Aggarwal, H. K., Sood, S., Jain, D., Kaverappa, V., & Yadav, S. (2013). Evaluation of spectrum of peripheral neuropathy in predialysis patients with chronic kidney disease. Renal Failure, 35(10). https://doi.org/10.3109/0886022X.2013.828261
Ahmed, H., Zahran, A., & Issawi, R. (2020). Prevalence and etiology of end-stage renal disease patients on maintenance hemodialysis. Menoufia Medical Journal, 33(3).
Aninditha, T., Salim, H., & Wiratman, W. (2022). Saraf Tepi: Buku Ajar Neurologi.
Babu, M., Kiran, M., Ravindra, K., Srinivas, V., Kandregula, P., Vardhan, R., & Kumar, N. (2015). Clinical manifestation and prevalence of peripheral neuropathy and nerve dysfunction in patients with chronic kidney disease. International Journal of Research in Medical Sciences, 3(2). https://doi.org/10.5455/2320-6012.ijrms20150213
Bakre, A., Aradhey, P., Acharya, S., & Kumar, S. (2021). The relationship of electrophysiological parameters of uremic polyneuropathy and uremic toxins in patients with chronic kidney disease. Saudi Journal of Kidney Diseases and Transplantation, 32(5). https://doi.org/10.4103/1319-2442.344745
Damnjanovic, T., Novakovic, I., Milasin, J., Bunjevacki, V., Jekic, B., Cvijeticanin, S., & Lukovic, L. (2007). X chromosome imprinting in turner syndrome. Korean Journal of Genetics, 29(3).
Doshi, S., Moorthi, R. N., Fried, L. F., Sarnak, M. J., Satterfield, S., Shlipak, M., Lange-Maia, B. S., Newman, A. B., & Strotmeyer, E. S. (2020). Chronic kidney disease as a risk factor for peripheral nerve impairment in older adults: A longitudinal analysis of Health, Aging and Body Composition (Health ABC) study. PLoS ONE, 15(12 December). https://doi.org/10.1371/journal.pone.0242406
Duraisamy, A., & Parthasarathy, P. (2018). Study on prevalence of peripheral neuropathy among patients on hemodialysis. International Archives of Integrated Medicine, 5(10).
Fatima, R., Kumar, P., & Beg, M. (2021). Electrophysiological study of peripheral neuropathies in chronic kidney disease patients and relation of severity of peripheral neuropathy with degree of renal failure. International Journal of Advances in Medicine, 8(10). https://doi.org/10.18203/2349-3933.ijam20213713
Gondhali, G., Kundalwal, A., & Takalkar, A. A. (2019). Peripheral neuropathy in Chronic Kidney Diseases: prevalence and its correlates. International Journal of Advances in Medicine, 7(1). https://doi.org/10.18203/2349-3933.ijam20195621
Hassan, H. K., Khan, M. I., & Umer, T. (2019). Association of Peripheral Neuropathy in Chronic Kidney Disease (CKD).
Jasti, D. B., Mallipeddi, S., Anumolu, A., Vengamma, B., Sivakumar, V., & Kolli, S. (2018). A clinical and electrophysiological study of peripheral neuropathies in predialysis and dialysis patients: Our experience from South India. Journal of Association of Physicians of India, 66(June).
Jasti, D., Mallipeddi, S., Apparao, A., Vengamma, B., Sivakumar, V., & Kolli, S. (2017). A clinical and electrophysiological study of peripheral neuropathies in predialysis chronic kidney disease patients and relation of severity of peripheral neuropathy with degree of renal failure. Journal of Neurosciences in Rural Practice, 8(4). https://doi.org/10.4103/jnrp.jnrp_186_17
Khafagi, A. T., Yehia, M. A., Helmy, A. K., Hassan, W., & Abdelhakim, N. (2022). Effect of Erythropoietin-stimulating agent on uremic neuropathy in hemodialysis patients: a single-center open-label prospective study. Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 58(1). https://doi.org/10.1186/s41983-022-00477-7
Kramer, H. (2010). The National Kidney Foundation’s Kidney Disease Outcomes Quality Initiative (KDOQI) Grant Initiative: Moving Clinical Practice Forward. In American Journal of Kidney Diseases (Vol. 55, Issue 3). https://doi.org/10.1053/j.ajkd.2009.11.001
Krishnan, A. V., & Kiernan, M. C. (2009). Neurological complications of chronic kidney disease. In Nature Reviews Neurology (Vol. 5, Issue 10). https://doi.org/10.1038/nrneurol.2009.138
Krishnan, A. V., Phoon, R. K. S., Pussell, B. A., Charlesworth, J. A., Bostock, H., & Kiernan, M. C. (2005). Altered motor nerve excitability in end-stage kidney disease. Brain, 128(9). https://doi.org/10.1093/brain/awh558
Levin, A., Stevens, P. E., Bilous, R. W., Coresh, J., De Francisco, A. L. M., De Jong, P. E., Griffith, K. E., Hemmelgarn, B. R., Iseki, K., Lamb, E. J., Levey, A. S., Riella, M. C., Shlipak, M. G., Wang, H., White, C. T., & Winearls, C. G. (2013). Kidney disease: Improving global outcomes (KDIGO) CKD work group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. In Kidney International Supplements (Vol. 3, Issue 1). https://doi.org/10.1038/kisup.2012.73
M. Al-Shazly, S., Ali Saeed Hassan, M., Fathi Ali Hamed, E.-S., & Mahmoud Abd El-Aziz Mohammad, M. (2020). THE PREVALENCE OF PERIPHERAL NEUROPATHY IN HEMODIALYSIS PATIENTS AT AL-AZHAR UNIVERSITY HOSPITAL IN NEW DAMIETTA CITY. Al-Azhar Medical Journal, 49(2). https://doi.org/10.21608/amj.2020.82580
Perkins, B., & Bril, V. (2014). Electrophysiologic testing in diabetic neuropathy. In Handbook of Clinical Neurology (Vol. 126). https://doi.org/10.1016/B978-0-444-53480-4.00018-7
Poernomo, H., Mudjiani, B., & Djoenaidi, W. (2003). Petunjuk praktis elektrodiagnostik. Bagian Ilmu Penyakit Saraf Fakultas Kedokteran Universitas Airlangga. Surabaya: AirlanggaUniversity Press. H, 199–255.
Raja, R. A., & Ashwinth. (2020). Prevalence of Peripheral Neuropathy in Chronic Kidney Disease. JMSCR, 8(11), 229–231. https://doi.org/https://dx.doi.org/10.18535/jmscr/v8i11.39
Ramírez, B. V., & Gómez, P. A. B. (2011). Uraemic neuropathy: A review. In International Journal of Genetics and Molecular Biology (Vol. 3, Issue 11). https://doi.org/10.5897/IJGMB11.022
Rathnakumar, G., Jose, J. P., & Anandan, H. (2018). Peripheral nerve dysfunction in chronic kidney disease. Int J Sci Stud, 5(10), 123–125.
Rizki, M. R. (2022). HUBUNGAN KADAR HORMON PARATIROID DENGAN NEUROPATI UREMIKUM PADA PASIEN PENYAKIT GINJAL KRONIK. Universitaas Andalas.
Shekar, C. P., Narisetti, V., Kumar, K. S., & Praveen, C. H. (2017). To study the spectrum of peripheral neuropathy in chronic kidney disease patients. International Archives of Integrated Medicine, 4.
Sultan, L. I. (2007). Evaluation of the clinical and neurophysiologic parameters of peripheral nerve functions in uremic Egyptian patients. Egypt J Neurol Psychiatr Neurosurg, 44, 473–487.
Supriyanto, T. (2015). Pengaruh Methylcobalamin terhadap Skor Neuropati dan Hilangnya Sensasi Protektif pada Pasien Penyakit Ginjal Kronis dengan Neuropati Uremikum. UNS (Sebelas Maret University).
Zamroni, Asmedi, A., & Nuradyo, D. (2016). Neuropathy symptom score dan neuropathy deficit score sebagai skor diagnostik neuropati diabetik. Berkala Neurosains, 15(1).