Antibacterial Potential of Parem Karo to Treat Staphyloccocus aureus Infection in Diabetic Foot Patients
Main Article Content
Jenny Alfa Dilla Br Tarigan
Novitaria Br Sembiring*
Roy Idrianto Bangar S.
One of the chronic and serious complications of diabetes mellitus is diabetic foot. Staphylococcus aureus bacteria is the most common bacteria found in this type of wound. The purpose of this study is to determine the antibacterial activity of parem Karo, which is one of the traditional medicines of the ethnic culture of the Karo tribe which is rich in spices. The results showed inhibitory activity at higher concentrations with the largest average inhibition diameter at 75% concentration against Staphyloccocus aureus bacteria (8.23 ± 0.72 mm) followed by 50% concentration with an average inhibition diameter (7.52 ± 0.2 mm) and at 25% concentration showed no inhibition zone at all. The conclusion obtained from this study is that there is antibacterial activity of Karo hot parem extract at a concentration of 75% and 50% against the growth of Staphyloccocus aureus bacteria.
Abdullah, V. I., Wahidin, W., Wibowo, D. P., & Mariani, R. (2023). Cross-Cultural Analysis of the Role of Traditional Medicine in Health Access in Indonesia. West Science Interdisciplinary Studies, 1(10). https://doi.org/10.58812/wsis.v1i10.279
Alouw, G., Fatimawali, F., & Lebang, J. S. (2022). Uji Aktivitas Antibakteri Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Terhadap Bakteri Staphylococcus aureus DAN Pseudomonas aeruginosa Dengan Metode Difusi Sumuran. Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ), 5(1). https://doi.org/10.35799/pmj.v5i1.41430
Charisma, A. M., Wahyuni, K. I., Ningsih, A. W., Sukardiman, & Syahrani, A. (2022). Study Of Drying Methods And Extraction Methods On Phenolic Contenct. In ICoGEMT.
Febriyanti, R. M., Saefullah, K., Susanti, R. D., & Lestari, K. (2024). Knowledge, attitude, and utilization of traditional medicine within the plural medical system in West Java, Indonesia. BMC Complementary Medicine and Therapies, 24(1). https://doi.org/10.1186/s12906-024-04368-7
Firhat, E., Dhyta, K. L., Tusy, T., & Fransisca, S. (2022). Comparison Of The Length Of Stay Of Covid-19 Patients With Comorbid Diabetes Mellitus By Gender At Natar Medika Hospital South Lampung In 2021. PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS, 1(2), 47–52. https://doi.org/10.55047/comorbid.v1i2.155
Handoyo, D. L. Y. (2020). The Influence Of Maseration Time (Immeration) On The Vocity Of Birthleaf Extract (Piper Betle). Jurnal Farmasi Tinctura, 2(1), 34–41. https://doi.org/10.35316/tinctura.v2i1.1546
Hasanah, R. U., Yuziani, & Sri Rahayu, M. (2023). Uji Efektivitas Antibakteri Ekstrak Etanol Daun Sukun (Artocarpus Altilis) Terhadap Pertumbuhan Bakteri Staphylococcus Aureus. Jurnal Ilmiah Manusia Dan Kesehatan, 6(1), 11–18. https://doi.org/10.31850/makes.v6i1.1659
Kasole, R., Martin, H. D., & Kimiywe, J. (2019). Traditional medicine and its role in the management of diabetes mellitus: “patients’’ and herbalists’ perspectives".” Evidence-Based Complementary and Alternative Medicine, 2019. https://doi.org/10.1155/2019/2835691
Kristiana, M., Fitriyana, F., & Kurnyawaty, N. (2023). Pengaruh Waktu Maserasi Terhadap Senyawa Flavonoid Dari Umbi Bawang Dayak. JURNAL TEKNIK KIMIA VOKASIONAL (JIMSI), 3(2).
Laksono, A. D., Wulandari, R. D., Nantabah, Z. K., Agustina, Z. A., Aimanah, I. U., Rukmini, R., Fitrianti, Y., Wardhani, Y. F., Effendi, D., Suharmiati, S., Handayani, L., & Pratiwi, N. L. (2020). The Concept of Illness among Ethnic Groups in Indonesia: A Meta-Ethnographic Study. Systematic Reviews in Pharmacy, 11(9).
Mareny, R. (2020). Profil Pembuatan Obat Tradisional (Kuning) Karo di Daerah Berastagi. Health Journal “Love That Renewed,” 8(2). https://doi.org/10.55912/jks.v8i2.86
Millah, U. (2021). Identifikasi Bakteri Staphylococcus Sp. Pada Pasien Diabetes Mellitus Dengan Komplikasi Luka Gangren. STIKes Ngudia Husada Madura.
Nasution, J., Amrul, H. M. Z. ., & Dasopang, E. S. (2022). Etnomedisin Karo di Sumatera Utara. JURNAL BIOLOGI PAPUA, 14(1), 72–77. https://doi.org/10.31957/jbp.1879
Roza, R. M., Fitmawati, Kapli, H., & Suzanti, F. (2023). Antibacterial Activity of Extracts of Wild Mango (Mangifera spp.), Ruellia tuberosa L and Leucobryum sp. Causes of Gangrene in Patients with Diabetes Mellitus. Jurnal Biologi Tropis, 23(1), 155–163. https://doi.org/10.29303/jbt.v23i1.4339
Sembiring, N. B., Lubis, A. A., Karo, R. M. B., & Hidayat, A. (2023). Skrinning fitokimia komponen bioaktif Parem Karo. Buletin Kedokteran & Kesehatan Prima, 2(2), 32–38. https://doi.org/10.34012/bkkp.v2i2.4798
